Institute of Biochemistry
Faculty of Medicine
University of Ljubljana

Vrazov trg 2
SI 1000, Ljubljana

Tel: +386-1-543-7672
Fax: +386-1-543-7641



Laboratory for molecular basis of hormone-dependent diseases and biomarkers (0381-059)




2021 I2020 I2019 I 2018


A review manuscript by Prof. Dr. Trevor M. Penning from University of Pennsylvania Perelman School of Medicine, Philadelphia USA. and Prof. Dr. Tea Lanišnik Rižner has been published in Pharmacological Reviews (IF 25.468)

7th Meeting of the BioEndoCar consortium was organized on 27th and 28th of May, 2021 as a webconference.

Prof. Dr. Jerzy Adamski, Professor emeritus at Helmholtz Zentrum Munich, Technical University of Munich, Institute of Experimental Genetics, Germany, Visiting Parkway Pantai Professor in Medicine and Healthy Ageing, Yong Loo Lin School of Medicine, National University of Singapore, Singapore and Editor-in-Chief, Journal of Steroid Biochemistry and Molecular Biology (Elsevier) joined University of Ljubljana Faculty of Medicine and our reseach group as a Visiting Scientist/Professor.


Scientific article by T. Knific et al. published in Nature's Scientific Reports has been awarded the ARRS Odlični v znanosti (Excellent in Science) award for 2020.

6th Meeting of the BioEndoCar consortium was organized on 10th and 11th of December, 2020 as a webconference.

Renata Pavlič, Teja Klančič and Klara Gregorič are winners of the Under 34 Competition at the 19th World Congress of Gynecological Endocrinology, organized between 2nd and 5th of December 2020. Two oral and four poster presentations of our research group were held via online platform; Renata Pavlič: Altered profile of E1-S transporters in endometrial cancer: lower protein levels of ABCG2 and OSTb and up-regulation of SLCO1B3 expression, and Maja Pušić: Discovery of potential biomarkers for peritoneal endometriosis using antibody array approach, Maša Sinreih: Medroxyprogesterone acetate, dienogest and dydrogesterone have different effects on expression of inflamatory response genes in a model cell line of peritoneal endometriosis , Marija Gjorgoska: Studies of estrogen formation in model cell lines of ovarian and endometrial cancer and Eva Hafner: Does black cohosh affect systemic estrogen levels in postmenopausal women? and BioEndoCar: in search of new Biomarkers for Diagnosis and Prognosis of Endometrial Carcinoma

Eva Hafner's abstract Project BioEndoCar: Proteomic and metabolomic approaches for discovery of diagnostic and prognostic biomarkers for endometrial carcinoma was selected for oral presentation at the TranSYS Online Training school held online between 22nd and 27th November, 2020.

Members of the group presented their work at 15th CFGBC online Symposium, 15th June 2020. Maša Sinreih et al.: Halogenated estrone derivatives as inhibitors of AKR1C1-C3 enzymes, Teja Klančič et al.: Seventeen possible novel biomarkers of peritoneal endometriosis discovered by antibody arrays, Renata Pavlič et al.: Altered local estrogen biosynthesis, metabolism and transport of steroid precursors in model cell lines of endometrial cancer of different grades, Eva Hafner et al.: Discovering novel diagnostic and prognostic Biomarkers for Endometrial Carcinoma by a combination of proteomics and metabolomics – BioEndoCar and Klara Gregorič et al.: The effects of Cimicifuga racemosa extract on expression of E1-S transporters and estrogen biosynthetic and metabolic genes in endometrial and ovarian cell lines.

5th Meeting of the BioEndoCar consortium was organized on 9th and 10th of June, 2020 as a webconference.


Head of the group and project coordinator (Tea Lanišnik Rižner) attended the 4th  Meeting of the BioEndoCar project, Medical University Lublin, Lublin, 5th to 6th December 2019.

The research group was active at the 21st ESGO Congress, Athens, Greece, 2nd-5th November 2019. Renata Pavlič et al.: Decreased expression of ABCG2 and SLC51B in endometrial cancer (doi:10.1136/ijgc-2019-ESGO.144.); Kristina Marton et al.: The effects of Cimicifuga racemosa extract on endometrial and ovarian cancer cell lines (doi:10.1136/ijgc-2019-ESGO.611.); Tamara Knific et al.: Biomarkers for diagnosis and prognosis of endometrial carcinoma: BioEndoCar (doi:10.1136/ijgc-2019-ESGO.612.); Tamara Knific et al.: Decreased s-Tie2 plasma concentration in patients with endometrioid endometrial cancer (doi:10.1136/ijgc-2019-ESGO.613.).

Open doors day at Faculty of Medicine, 4th October 2019. Tea Lanišnik Rižner, Maša Sinreih and Renata Pavlič presented the latest results and current research interests of our Laboratory for molecular basis of hormone-dependent diseases and biomarkers.

The research group attended the 13th SBD Meeting, Dobrna, Slovenia, 24th-27th September 2019. Renata Pavlič et al.: Important roles of OATP, OAT and ABC transporters in endometrial cancer; Tamara Knific et al.: Diagnostic and/or prognostic value of plasma concentration of angiogenic factors in endometrioid endometrial cancer; Kristina Marton et al.: The effects of Cimicifuga racemose extract on hormone‐ dependent malignant gynaecological diseases; Neža Lipušček et al.: Oestrane Derivatives as New Inhibitors of Steroidogenic Enzymes and as Anti‐Proliferative Agents.

Dr. Janina Tokarz, Head of functional Metabolomics at Research Unit Molecular Endocrinology and Metabolism, Helmholtz Zentrum München, joined the group as a visiting scientist (9th-20th September 2019, funded by bilateral grant BI-DE/18-19-004) and gave a lecture entitled „Catabolism of glucocorticoids – from an unknown enzyme in zebrafish to human complexity”.

Members of the group (Tamara Knific and Tea Lanišnik Rižner) attended the 3rd Meeting of the BioEndoCar project, Maastricht University Medical Centre, The Netherlands, 27th-28th June 2019.

Invited lecture at the Pre-Congress Course Diagnosing endometriosis and adenomyosis: Today and tomorrow, ESHRE 2019, Vienna, Austria, 23rd June, 2019. Tea Lanišnik Rižner: Proteomics and metabolomics – Discovery of diagnostic biomarkers of endometriosis.

Presentation at the ENITEC 2019, Liverpool, Great Britain, 13th-14th June, 2019. Tea Lanišnik Rižner: Biomarkers for diagnosis and prognosis of endometrial carcinoma – Update on the ERA-NET Transcan2 project.


Lecture at the 17th International Congress on Hormonal Steroids and Hormones and Cancer, Stellenbosh, South Africa, 26th-29th November 2018. Tea Lanišnik Rižner: Altered levels of ABC, OATP and OST transporters may contribute to enhanced E2 formation in endometrial cancer.

Invited lecture at the FEBS3+ Meeting, Siófok, Hungary, 2nd-5th September, 2018. Tea Lanišnik Rižner: Estrogen biosynthesis and oxidative metabolism in endometrial cancer.

Oral presentations at the 4th European Congress on Endometriosis, Vienna, Austria, 22nd-24th November 2018. Renata Pavlič: Progestins affect expression of inflammatory genes in a model cell line of peritoneal endometriosis; Tamara Knific: Potential of plasma lipid metabolites for diagnosis of endometriosis.

Krka award for Ph. D. Thesis, Krka, Novo mesto, 19th October 2018. Tamara Knific: Identification of novel biomarkers for endometriosis and endometrial cancer using proteomic and metabolomic approaches.