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Institute of Biochemistry Vrazov trg 2 Tel: +386-1-543-7672 |
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Laboratory for molecular basis of hormone-dependent diseases and biomarkers (0381-059) |
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RESEARCH I
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NEWS2023 I 2022 I 2021 I 2020 I2019 I 2018 2023Workshop on Importance of Biobanking in Biomarker Discovery was organized by the P1-390 programme group and the TRENDO consortium on 19th and 20th October 2023. Tea Lanišnik Rižner and Tadeja Režen acted as Scientific and Organizing Committee. Book of abstracts is available online. Marija Gjorgoska was awarded a Short Oral Presentation Award at the Steroid Congress 2023 that took place on October 6-8, 2023 as an online event. The congress had over 200 participants from 28 countries. Tea Lanišnik Rižner was an invited speaker at the SUPA-Conference on Sulfation Pathways-Highlighting Sulfated Signalling Molecules in Health & Disease, which took place from 12th until 14th September 2023 in Birmigham, UK, and gave a lecture entitled Steroid sulphatase and sulphotransferases in gynaecological cancers. At the Scientific symposium with international participation on the occasion of the 50th anniversary of the Institute of Biochemistry and Molecular Genetics, which took place on 6th and 7th of July 2023, the session MOLECULAR MECHANISMS AND BIOMARKERS IN HORMONE-DEPENDENT DISEASES included a presentation of our group and invited talks by Prof. Adamski (Helmholtz Zentrum München, Germany; National University of Singapore, Singapore; UL MF) and Prof. Karl Storbeck (Stellenbosch University, SAR) and two short talks by Marija Gjorgoska and Luka Roškar. The groups led by Prof. Dr. Tea Lanišnik Rižner and Prof. Dr. Špela Smrkolj were the local organizers of the annual ENITEC meeting, which was be held in Ljubljana (Faculty of Medicine, Korytkova 2, Ljubljana) + online on 7th and 8th of June 2023. The programme will start with a keynote lecture and continue with 16 presentations by ENITEC members from 7 European countries. Tea Lanišnik Rižner was an invited speaker at the 28th EBCOG Congress, Krakow, Poland, 18th-22th of May 2023 with a lecture entitled Proteomics and transcriptomics approaches for biomarker discovery in endometriosis. Marija Gjorgoska visited the laboratory led by Dr. Angela Taylor at the Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham UK, during 17th of April and 7th of May 2023, as a recipient of the Practical Skills grant from the Society of Endocrinology. Biomarker discovery study TGFBI as a candidate biomarker for non-invasive diagnosis of early-stage endometriosis by Vid Janša, Maja Pušić Novak, Helena Ban Frangež and Tea Lanišnik Rižner has been published in Human Reproduction (IF 6.353 ). 2022Vid Janša is the recipient of the International Medis Awards for Medical Research for his work entitled Proteomic analysis of peritoneal fuid identifed COMP and TGFBI as new candidate biomarkers for endometriosis , published in Scientific Reports. Tea Lanišnik Rižner was awarded with Zois Recognition for Outstanding Scientific Achivements. Marija Gjorgoska is a recipient of a Practical Skills grant from the Society of Endocrinology. A review manuscript entitled Integration of androgen hormones in endometrial cancer by Marija Gjorgoska and Tea Lanišnik Rižner has been published in Trends of Endocrinology and Metabolism (I.F.10.586). Maja Pušić, Renata Pavlič and Nika Marolt are winners of the Under 34 Competition at the 20th World Congress of Gynecological Endocrinology, organized between 11th and 14th of May 2020. Three oral and two poster presentations of our research group were presented on site and via online platform. The Final Symposium of the BioEndoCar project was organized on 24th and 25th of March, 2022 in Hotel Marko, Portorož, Slovenia + on-line. The programme included 8 sessions with 28 invited speakers and 5 short oral presentations. More than 90 participants attended the symposium either onsite or online. The abstracts of presentations can be found in Book of abstracts. Head of the group Tea Lanišnik Rižner joined the Editorial Board of the journal Human Reproduction (I.F. 6.918) as an Associate Editor. 2021Review article Aldo-keto reductases and cancer drug resistance co-authored by T. Lanišnik Rižner published in Pharmacological Reviews has been awarded the ARRS Excellent in Science (Odlični v znanosti) award for 2021. Luka Roškar is the recipient of the 2021 International Medis Award for Medical Research for his work entitled Tie-2, G-CSF, and Leptin as Promising Diagnostic Biomarkers for Endometrial Cancer: A Pilot Study. 8th Meeting of the BioEndoCar consortium was organized on 25th and 26th of November, 2021 as a webconference. Marija Gjorgoska is a recipient of Krka special recognition for her M.Sc thesis entitled, „Studies of estrogen formation in model cell lines of ovarian and endometrial cancers“. The research group was active at the 22nd ESGO Congress, 23rd-25th October, 2021, a hybrid event. M. Gjorgoska et al.: Local androgen synthesis and metabolism in endometrial and ovarian cancer; E. Hafner et al.: BioEndoCar: omics approaches for diagnosis and prognosis of endometrial cancer; R. Pavlič et al.: In RL95-2 and KLE model cell lines of moderately and poorly differentiated endometrial carcinoma, estrogens can be formed via the sulfatase pathway and M. Sinreih et al.: Cimicifuga racemosa extract effects on endometrial and ovarian cell lines. MSCA RISE project TRENDO coordinated by Westfaelische Wilhelms-Universitaet started on 1st of August 2021. Group members presented their work at the 45th FEBS Virtual Congress, 3rd- 8th July, 2021. M. Gjorgoska et al.: Differences in the sulfatase pathway activity highlight a heterogeneity in endometrial and ovarian cancer cell lines; E. Hafner et al.: Possible effects of black cohosh extracts on estrogen levels in postmenopausal women and Metabolomic and proteomic approaches for discovery of diagnostic and prognostic biomarkers for endometrial carcinoma - BioEndoCar; M. Pusic et al.: Antibody microarrays for detection of peritoneal endometriosis biomarker candidates; R. Pavlic et al.: Lower protein levels of ABCG2 and OSTβ and up-regulation of SLCO1B3 expression in endometrial cancer and M. Sinreih et al.: Progestins affect expression of inflamatory response genes in a model cell line of peritoneal endometriosis 12-Z . A review manuscript by Prof. Dr. Trevor M. Penning from University of Pennsylvania Perelman School of Medicine, Philadelphia USA and Prof. Dr. Tea Lanišnik Rižner has been published in Pharmacological Reviews (IF 25.468) . Marija Gjorgoska's abstract Combined liquid chromatography-tandem mass spectrometry method for quantification of androgens and 11-oxyandrogens was selected for oral presentation at the 16th CFGBC Symposium held online on 17th of June, 2021. 7th Meeting of the BioEndoCar consortium was organized on 27th and 28th of May, 2021 as a webconference. Prof. Dr. Jerzy Adamski, Professor emeritus at Helmholtz Zentrum Munich, Technical University of Munich, Institute of Experimental Genetics, Germany, Visiting Parkway Pantai Professor in Medicine and Healthy Ageing, Yong Loo Lin School of Medicine, National University of Singapore, Singapore and Editor-in-Chief, Journal of Steroid Biochemistry and Molecular Biology (Elsevier) joined University of Ljubljana Faculty of Medicine and our reseach group as a Visiting Scientist/Professor. 2020Scientific article by T. Knific et al. published in Nature's Scientific Reports has been awarded the ARRS Odlični v znanosti (Excellent in Science) award for 2020. 6th Meeting of the BioEndoCar consortium was organized on 10th and 11th of December, 2020 as a webconference. Renata Pavlič, Teja Klančič and Klara Gregorič are winners of the Under 34 Competition at the 19th World Congress of Gynecological Endocrinology, organized between 2nd and 5th of December 2020. Two oral and four poster presentations of our research group were held via online platform; Renata Pavlič: Altered profile of E1-S transporters in endometrial cancer: lower protein levels of ABCG2 and OSTb and up-regulation of SLCO1B3 expression, and Maja Pušić: Discovery of potential biomarkers for peritoneal endometriosis using antibody array approach, Maša Sinreih: Medroxyprogesterone acetate, dienogest and dydrogesterone have different effects on expression of inflamatory response genes in a model cell line of peritoneal endometriosis , Marija Gjorgoska: Studies of estrogen formation in model cell lines of ovarian and endometrial cancer and Eva Hafner: Does black cohosh affect systemic estrogen levels in postmenopausal women? and BioEndoCar: in search of new Biomarkers for Diagnosis and Prognosis of Endometrial Carcinoma Eva Hafner's abstract Project BioEndoCar: Proteomic and metabolomic approaches for discovery of diagnostic and prognostic biomarkers for endometrial carcinoma was selected for oral presentation at the TranSYS Online Training school held online between 22nd and 27th November, 2020. Members of the group presented their work at 15th CFGBC online Symposium, 15th June 2020. Maša Sinreih et al.: Halogenated estrone derivatives as inhibitors of AKR1C1-C3 enzymes, Teja Klančič et al.: Seventeen possible novel biomarkers of peritoneal endometriosis discovered by antibody arrays, Renata Pavlič et al.: Altered local estrogen biosynthesis, metabolism and transport of steroid precursors in model cell lines of endometrial cancer of different grades, Eva Hafner et al.: Discovering novel diagnostic and prognostic Biomarkers for Endometrial Carcinoma by a combination of proteomics and metabolomics – BioEndoCar and Klara Gregorič et al.: The effects of Cimicifuga racemosa extract on expression of E1-S transporters and estrogen biosynthetic and metabolic genes in endometrial and ovarian cell lines. 5th Meeting of the BioEndoCar consortium was organized on 9th and 10th of June, 2020 as a webconference. 2019Head of the group and project coordinator (Tea Lanišnik Rižner) attended the 4th Meeting of the BioEndoCar project, Medical University Lublin, Lublin, 5th to 6th December 2019. The research group was active at the 21st ESGO Congress, Athens, Greece, 2nd-5th November 2019. Renata Pavlič et al.: Decreased expression of ABCG2 and SLC51B in endometrial cancer (doi:10.1136/ijgc-2019-ESGO.144.); Kristina Marton et al.: The effects of Cimicifuga racemosa extract on endometrial and ovarian cancer cell lines (doi:10.1136/ijgc-2019-ESGO.611.); Tamara Knific et al.: Biomarkers for diagnosis and prognosis of endometrial carcinoma: BioEndoCar (doi:10.1136/ijgc-2019-ESGO.612.); Tamara Knific et al.: Decreased s-Tie2 plasma concentration in patients with endometrioid endometrial cancer (doi:10.1136/ijgc-2019-ESGO.613.). Open doors day at Faculty of Medicine, 4th October 2019. Tea Lanišnik Rižner, Maša Sinreih and Renata Pavlič presented the latest results and current research interests of our Laboratory for molecular basis of hormone-dependent diseases and biomarkers. The research group attended the 13th SBD Meeting, Dobrna, Slovenia, 24th-27th September 2019. Renata Pavlič et al.: Important roles of OATP, OAT and ABC transporters in endometrial cancer; Tamara Knific et al.: Diagnostic and/or prognostic value of plasma concentration of angiogenic factors in endometrioid endometrial cancer; Kristina Marton et al.: The effects of Cimicifuga racemose extract on hormone‐ dependent malignant gynaecological diseases; Neža Lipušček et al.: Oestrane Derivatives as New Inhibitors of Steroidogenic Enzymes and as Anti‐Proliferative Agents. Dr. Janina Tokarz, Head of functional Metabolomics at Research Unit Molecular Endocrinology and Metabolism, Helmholtz Zentrum München, joined the group as a visiting scientist (9th-20th September 2019, funded by bilateral grant BI-DE/18-19-004) and gave a lecture entitled „Catabolism of glucocorticoids – from an unknown enzyme in zebrafish to human complexity”. Members of the group (Tamara Knific and Tea Lanišnik Rižner) attended the 3rd Meeting of the BioEndoCar project, Maastricht University Medical Centre, The Netherlands, 27th-28th June 2019. Invited lecture at the Pre-Congress Course Diagnosing endometriosis and adenomyosis: Today and tomorrow, ESHRE 2019, Vienna, Austria, 23rd June, 2019. Tea Lanišnik Rižner: Proteomics and metabolomics – Discovery of diagnostic biomarkers of endometriosis. Presentation at the ENITEC 2019, Liverpool, Great Britain, 13th-14th June, 2019. Tea Lanišnik Rižner: Biomarkers for diagnosis and prognosis of endometrial carcinoma – Update on the ERA-NET Transcan2 project. 2018Lecture at the 17th International Congress on Hormonal Steroids and Hormones and Cancer, Stellenbosh, South Africa, 26th-29th November 2018. Tea Lanišnik Rižner: Altered levels of ABC, OATP and OST transporters may contribute to enhanced E2 formation in endometrial cancer. Invited lecture at the FEBS3+ Meeting, Siófok, Hungary, 2nd-5th September, 2018. Tea Lanišnik Rižner: Estrogen biosynthesis and oxidative metabolism in endometrial cancer. Oral presentations at the 4th European Congress on Endometriosis, Vienna, Austria, 22nd-24th November 2018. Renata Pavlič: Progestins affect expression of inflammatory genes in a model cell line of peritoneal endometriosis; Tamara Knific: Potential of plasma lipid metabolites for diagnosis of endometriosis. Krka award for Ph. D. Thesis, Krka, Novo mesto, 19th October 2018. Tamara Knific: Identification of novel biomarkers for endometriosis and endometrial cancer using proteomic and metabolomic approaches. |
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