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RESEARCH
The research interests of our group are the roles of
steroid hormones in etiology of steroid hormone dependent diseases and
identification of novel drug targets and diagnostic biomarkers of these
diseases.
Steroid hormones have pivotal roles in human homeostasis. When their actions are disturbed, this can lead to the
development of hormone-dependent diseases, including hormone-dependent cancers and several benign diseases. There is a
compelling need to better understand the etiology of these common diseases. In this respect our group is investigating the mechanisms
of steroid hormone action under these pathological conditions. We are studying the individual estrogen, progesterone and androgen biosynthetic
and metabolizing enzymes, the individual metabolites formed, the receptors, and the components of the intracellular signaling
cascades in diseased tissue and in model cell lines of endometrial cancer, ovarian cancer, breast cancer, and endometriosis.
Our objectives are
1) to further the understanding of steroid actions in hormone-dependent diseases
and
2) to contribute to the identification of novel drug targets and diagnostic biomarkers among the estrogen and
progesterone biosynthetic and metabolizing enzymes, and their corresponding classical or membrane-bound receptors and
disease-associated metabolites.
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Representative publications:
MAROLT Nika, PAVLIČ Renata, KREFT Tinkara, GJORGOSKA Marija, LANIŠNIK RIŽNER Tea.
Targeting estrogen metabolism in high-grade serous ovarian cancer shows promise
to overcome platinum resistance. Biomedicine & pharmacotherapy.
2024, vol. 177, 117069, p. 1-17,
doi: 10.1016/j.biopha.2024.117069.
[COBISS.SI-ID 202256387]
GJORGOSKA Marija, ŠTURM Lea, LANIŠNIK RIŽNER Tea. Pre-receptor regulation
of 11-oxyandrogens differs between normal and cancerous endometrium and
across endometrial cancer grades and molecular subtypes. Frontiers in endocrinology.
2024, vol. 15, iss. 1404804, p. 1-12,
doi: 10.3389/fendo.2024.1404804.
[COBISS.SI-ID 203016707]
LANIŠNIK RIŽNER Tea, GJORGOSKA Marija. Steroid sulfatase and sulfotransferases
in the estrogen and androgen action of gynecological cancers :
current status and perspectives. Essays in Biochemistry.
2024, vol. 12, iss. ebc20230096, p. 1-13,
doi: 10.1042/EBC20230096.
[COBISS.SI-ID 202276355]
LANIŠNIK RIŽNER Tea, ROMANO Andrea. Targeting the formation of estrogens for treatment of hormone dependent diseases–current status.
Frontiers in pharmacology. 2023.
doi: 10.3389/fphar.2023.1155558.
[COBISS.SI-ID 150180099]
PENNING M. Trevor, JONNALAGADDA Sravan, TRIPPIER C. Paul,
LANIŠNIK RIŽNER Tea. Aldo-Keto Reductases and Cancer Drug Resistance.
Pharmacological Reviews, 2021, 73:1-22, IF 25.468,
doi: 10.1124/pharmrev.120.000122.
[COBISS.SI-ID 67481603]
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There is a great need for early diagnosis and
individualized patient-oriented treatments for hormone-dependent diseases. In collaboration with the Department of Gynaecology at the
University Clinical Centre, Ljubljana, we are addressing the lack of appropriate biomarkers for diagnosis of endometrial cancer, ovarian
cancer and endometriosis. To accomplish these aims we are using targeted cutting-edge transcriptomics, proteomics and metabolomics approaches.
Our objectives are
1) to provide diagnostic and prognostic algorithms with high sensitivity and
specificity that will be available for further clinical validation and application, and will thus pave the way for future
development of diagnostic assays, and |
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2) to identify proteins associated with diseases that may serve as tissue markers
following successful validation in larger sets of archival pathological specimens, and demonstrated correlation with disease outcome.
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Representative publications:
JANŠA Vid, PUŠIĆ NOVAK Maja, BAN Helena, LANIŠNIK RIŽNER Tea.
TGFBI as a candidate biomarker for non-invasive diagnosis of early-stage endometriosis.
Human reproduction. [Online ed.]. 2023.
doi: 10.1093/humrep/dead091.
[COBISS.SI-ID 150991875]
ROMANO Andrea, LANIŠNIK RIŽNER Tea, WERNER Henrica Maria Johanna,
SEMCZUK Andrzej, LOWY Camille, SCHRÖDER Christoph, GRIESBECK Anne,
ADAMSKI Jerzy, FISHMAN Dmytro, TOKARZ Janina.
Endometrial cancer diagnostic and prognostic algorithms based
on proteomics, metabolomics, and clinical data: a systematic review. 2023.
doi: 10.3389/fonc.2023.1120178.
[COBISS.SI-ID 147451139]
EMOND Jean-Philippe, CARON Patrick, PUŠIĆ NOVAK Maja,
TURCOTTE Véronique, SIMONYAN David, VOGLER Andrej,
OSREDKAR Joško, LANIŠNIK RIŽNER Tea, GUILLEMETTE Chantal.
Circulating estradiol and its biologically active metabolites
in endometriosis and in relation to pain symptoms.
Frontiers in endocrinology. 2023.
doi: 10.3389/fendo.2022.1034614.
[COBISS.SI-ID 136322563]
ROŠKAR Luka, PUŠIĆ Maja, ROŠKAR Irena, KOKOL Marko, PIRŠ Boštjan, SMRKOLJ Špela,
LANIŠNIK RIŽNER Tea. Models including preoperative plasma levels
of angiogenic factors, leptin and IL-8 as potential biomarkers of endometrial cancer.
Frontiers in oncology. 2022.
doi: 10.3389/fonc.2022.972131.
[COBISS.SI-ID 128919555]
JANŠA Vid, KLANČIČ Teja, PUŠIĆ Maja, KLEIN Marco, VRTAČNIK BOKAL Eda,
BAN FRANGEŽ Helena, LANIŠNIK RIŽNER Tea. Proteomic analysis of peritoneal fluid
identified COMP and TGFBI as new candidate biomarkers for
endometriosis. Scientific Reports, 2021, Vol. 11, 20870.
doi: 10.1038/s41598-021-00299-2.
[COBISS.SI-ID 81004035 ]
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