Institute of Biochemistry
Faculty of Medicine
University of Ljubljana

Vrazov trg 2
SI 1000, Ljubljana
Slovenia

Tel: +386-1-543-7672
Fax: +386-1-543-7641

 



 

Laboratory for molecular basis of hormone-dependent diseases and biomarkers (0381-059)

RESEARCHMEMBERSFUNDINGTHESESAWARDSPUBLICATIONSCOLLABORATIONSEQUIPMENTNEWS
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THESES

PhD THESES

KNIFIC Tamara. Identification of novel biomarkers for endometriosis and endometrial cancer using proteomic and metabolomic approaches. 2018. [COBISS.SI-ID 33878489]

SINREIH Maša. Studies of progesterone metabolism and the roles of metabolites in endometrial cancer and endometriosis. 2015. [COBISS.SI-ID 279853824]

KOCBEK Vida. Study of potential biomarkers in ovarian endometriosis. 2013. [COBISS.SI-ID 782967]

BERANIČ Nataša. Study of progesterone metabolism, role of aldo-keto reductases and progestins in endometriosis. 2013. [COBISS.SI-ID 266472448]

HEVIR Neli. Studies on estrogen and progesterone metabolism in endometrial cancer and ovarian endometriosis. 2011. [COBISS.SI-ID 258770688]

BRUNSKOLE ŠVEGELJ Mojca. Structure/function relationship of short-chain dehydrogenases/reductases and their inhibitors. 2011 (supervisor Prof. Dr. Jure Stojan). [COBISS.SI-ID 256628736]

STARČEVIČ Štefan. Design, synthesis and evaluation of new nonsteroidal inhibitors of 17ß-hydroxysteroid dehydrogenase type 1. 2011 (supervisor Prof. Dr. Stanislav Gobec). [COBISS.SI-ID 3030385]

BROŽIČ Petra. Preparation of recombinant human hydroxysteroid dehydrogenases and study of their inhibitors. 2010. [COBISS.SI-ID 251130880]

ŠMUC Tina. Regulation of estrogen and progesterone action in endometriosis and endometrial cancer. 2009. [COBISS.SI-ID 244659200]

KRISTAN Katja. Structure/function relationship in fungal 17beta-hydroxysteroid dehydrogenase, a model enzyme of the short-chain dehydrogenase/reductase superfamily. 2005. [COBISS.SI-ID 2848020]



MSc THESES

GJORGOSKA Marija. Synthesis of estrogens in cell lines of endometrial and ovarian cancer. 2021. [COBISS.SI-ID 55705859]

KRISTAN Katja. Significance of individual amino acid residues for activity of 17beta-hydroxysteroid dehydrogenase from fungus Cochliobolus lunatus - preparation and characterization of mutant proteins. 2003. [COBISS.SI-ID 2621972]



BSc THESES

ŽUMER Alenka. Analysis of certain possible reaction mechanisms of 17[beta]-hydroxysteroid dehydrogenase from filamentous fungus Cochliobolus lunatus. 2014. [COBISS.SI-ID 4369528]

ŠKET Aleš. Detection of proteins AKR1B1 and AKR1B10 in endometrial cancer. 2013. [COBISS.SI-ID 30586073]

SVOLJŠAK Katja. Determination of presence of estrogen quinone detoxification enzymes in endometrial cancer. 2013. [COBISS.SI-ID 3446897]

ČESEN Marjeta. Derivatives of 2-phenylcinnamic acid as inhibitors of human hydroxysteroid dehydrogenases AKR1C1 and AKR1C3. 2011. [COBISS.SI-ID 3088497]

SINREIH Maša. New derivatives of antranilic acid as inhibitors of aldo/keto-reductases AKR1C1-AKR1C3. 2011. [COBISS.SI-ID 3054449]

BOŽNAR Polona. Implementation of Suzuki cross coupling reaction for preparation of indole and coumarin derivatives as potential inhibitors of 17ß-hydroksysteroid dehydrogenase type 1. 2011. [COBISS.SI-ID 2997105]

BERČIČ Nejc. Synthesis of coumarin derivatives as potencial inhibitors of 17ß-hydroxysteroid dehydrogenase type 1. 2011. [COBISS.SI-ID 2998129]

MEDAR Maja. Evaluation of CYP1B1 and COMT protein levels in endometrial cancer. 2010. [COBISS.SI-ID 2815089]

BARLE Nina. Expression of estrogen receptor alpha and polymorphisms of estrogen ESR 1 in endometrial cancer. 2008. [COBISS.SI-ID 2356593]

KERBLER Vanja. Flavonoids as inhibitors of recombinant trihydroxynaphthalene reductase from fungus Curvularia lunata. 2008. [COBISS.SI-ID 2434673]

KRAJNIK Mateja. Derivatives of cyclopentane and flavonoids as inhibitors of human hydroxysteroid dehydrogenase AKR1C3. 2008. [COBISS.SI-ID 2353265]

LOZIČ Eva. Expression studies of estrogen and progesterone receptors in endometrial cancer. 2008. [COBISS.SI-ID 1848911]

GOSTIČ Katja. Detection of protein AKR1C3 in ovarian cyst samples from female patients with ovarian endometriosis. 2007. [COBISS.SI-ID 2163825]

BAJC Gregor. Expression studies of 17[beta]-hydroxysteroid-dehydrogenase AKR1C3 in endometrial cancer. 2007. [COBISS.SI-ID 1737039]

ABRAHAMSBERG Jana. Derivatives of anthranilic acid as inhibitors of human hydroxysteroid dehydrogenase AKR1C1. 2007. [COBISS.SI-ID 2141553]

BEVK Alenka. Derivatives of cyclopentane, phthalimidie and pyriidine as inhibitors of human hydroxysteroid dehydrogenase AKR1C1. 2007. [COBISS.SI-ID 2106225]

ZORKO Karmen. Synthesis of nonphysiological substrate and searching for inhibitors of fungal trihydroxynaphthalene reductase. 2007. [COBISS.SI-ID 2143857]

GOMBOC Nataša. Derivatives of cinnamic acid as inhibitors of human hydroxysteroid dehydrogenases AKR1C1 and AKR1C3. 2006. [COBISS.SI-ID 1944433]

GOLOB Barbara. Naphthalene derivatives as inhibitors of human hydroxysteroid dehydrogenases AKR1C1 and AKR1C3. 2006. [COBISS.SI-ID 1980785]

BRUNSKOLE Mojca. Searching for inhibitors of trihydroxynaphthalene reductase from fungus Curvularia lunata as potential antimicotic drugs. 2006. [COBISS.SI-ID 1904753]

STARČEVIĆ Štefan. New cinnamic acid derivatives as inhibitors of 17ß-hydroxysteroid dehidrogenases. 2006. [COBISS.SI-ID 1888625]

KOVAČIČ Petra Brina. Significance of individual amino acid residues for substrate and coenzyme specificity of 17beta-hydroxysteroid dehydrogenase from the fungus Cochliobolus lunatus. 2006. [COBISS.SI-ID 1618767]

BROŽIČ Petra. Searching for inhibitors of recombinant human hydroxysteroid-dehidrigenase AKR1C3. 2005. [COBISS.SI-ID 1698161]

FURMAN Tjaša. Hepapeptide phage display library as a tool for searching potential peptide inhibitors of recombinant 17ß-hydroxysteroid-dehydrogenase from the fungus Cochliobolus lunatus. 2005. [COBISS.SI-ID 1842033]

BRADAČ Mateja. Phytoestrogens and cinnamic acid derivatives as inhibitors of recombinant human hydroxysteroid dehydrogenases AKR1C1 in AKR1C3. 2005. [COBISS.SI-ID 1731953]

BRAČUN Jure. Synthesis of derivatives of antranilic acid as potential ihibitors of human hydroxysteroid dehydrogenase AKR1C1. 2005. [COBISS.SI-ID 1703281]

ŠMUC Tina. Isolation and characterization of recombinant human hydroxysteroid dehydrogenase AKR1C3 and studies of AKR1C3 gene expression in endometrial cancer. 2004. [COBISS.SI-ID 26156293]

LAPORNIK Ajda. Preparation of recombinant human 20a-hydroxysteroid dehydrogenase (AKR1C1) and studies of AKR1C1 gene expression in endometrial cancer. 2004. [COBISS.SI-ID 1596017]

KRAJNC Katja. Phytoestrogens and cinnamic acid derivatives as inhibitors of recombinant 17[beta]-hydroxysteroid-dehydrogenase from the fungus Cochliobolus lunatus. 2004. [COBISS.SI-ID 1460337]

SOVA Matej. Synthesis and evaluation of cinnamic acid esters as inhibitors of recombinant 17ß-hydroksysteroid dehydrogenase from the fungus Cochliobolus lunatus. 2004. [COBISS.SI-ID 1499761]

MAČEK Melita Ana. Isolation and physiochemical characterization of recombinant 17[beta]-hydroxysteroid dehydrogenase (from the fungus Cochliobolus lunatus). 2002. [COBISS.SI-ID 2630008]