Institute of Biochemistry and Molecular Genetics
Faculty of Medicine
University of Ljubljana

Vrazov trg 2
SI 1000, Ljubljana
Slovenia

Tel (IBK): +386-1-543-7640
Tel (lab): +386-1-543-7652
E-mail: metka.lenassi@mf.uni-lj.si

 
 

Laboratory for Extracellular Vesicle Research
PI: Metka Lenassi

HOME  I  MEMBERS  I  RESEARCH  I  RESEARCH SUPPORT  I  TALKS & RECOGNITIONS  I  EQUIPMENT  I  LINKS  I 
line2
 

TALKS & RECOGNITIONS

Meetings and conferences where we presented our work:

2024

  • LENASSI, Metka. Understanding variability of blood EVs in healthy adults: relevance for biomarker discovery.
    Combivet & OH-boost Joint Conference 2024 "Unlocking the potential of extracellular vesicles in one health, food and feed", 24. – 25. 5. 2024, Tartu, Estonia

    • 2023

  • LENASSI, Metka. EV-based diagnostics: understanding variability of blood EVs in healthy adults.
    KSEV 2023, 12. – 14. 11. 2023, Jeju, Korea
  • LENASSI, Metka. Realizing the diagnostic potential of EVs - key challenges.
    2023 CSEV Annual Meeting, 20. – 22. 10. 2023, Shanghai, China
  • HOLCAR, Marija, MARIĆ, Ivica, TERTEL, Tobias, GORIČAR, Katja, MAVEC, Nina, ČEGOVNIK PRIMOŽIČ, Urška, ČERNE, Darko, LENASSI, Metka. Characteristics of plasma EVs in healthy adults and the influence of recent mild COVID-19
    15th Meeting of the Slovenian Biochemical Society, 20. – 23. 9. 2023, Portorož, Slovenia
  • HOLCAR, Marija, MARIĆ, Ivica, TERTEL, Tobias, GORIČAR, Katja, MAVEC, Nina, GIEBEL, Bernd, LENASSI, Metka. Characterization and interindividual variability of plasma extracellular vesicles in healthy adults.
    Small New World 2.0: joint meeting of Austrian Society for Extracellular Vesicles - ASEV, Hungarian Section for Extracellular Vesicles - HSEV, Slovenian Network for Extracellular Vesicles - SiN-EV, Serbian Society Extracellular Vesicles - SrbEVs. 4. – 5. 9. 2023, Graz, Austria
  • HOLCAR, Marija, MARIĆ, Ivica, TERTEL, Tobias, GORIČAR, Katja, MAVEC, Nina, GIEBEL, Bernd, LENASSI, Metka. Variability of blood-derived extracellular vesicles in healthy humans.
    Biochemistry and molecular genetics in medicine: Scientific Symposium with International Participation on the Occasion of the 50th Anniversary of the Institute of Biochemistry and Molecular Genetics (1972-2022) and the 30th Anniversary of the Medical Centre for Molecular Biology (1992-2022) at the Faculty of Medicine, University of Ljubljana: 6. – 7. 7. 2023, Ljubljana, Slovenia
  • HOLCAR, Marija, MARIĆ, Ivica, GORIČAR, Katja, TERTEL, Tobias, MAVEC, Nina, ČEGOVNIK PRIMOŽIČ, Urška, ČERNE, Darko, GIEBEL, Bernd, LENASSI, Metka. Interindividual variance of plasma EVs in healthy adults and the influence of clinical, demographic, and lifestyle parameters
    ISEV 2023 Annual Meeting, 17. – 21. 5. 2023, Seattle, Washington, USA
  • HOLCAR, Marija. Studies of blood plasma EVs: challenges of population selection and sample quality assessment
    ISEV workshop QuantitatEVs: Multiscale analyses, from bulk to single vesicle, 31.1. – 3. 2. 2023, Trento and Milano

    • 2022

  • LENASSI, Metka. Realizing the diagnostic potential of extracellular vesicles - key (remaining) challenges.
    METVES II, 24. 11. 2022, Delft, The Netherlands
  • LENASSI, Metka. EV-bound DNA, future biomarker in transplant medicine?
    Small New World, Joint Meeting of ASEV & GSEV, 28. – 29. 10. 2022, Salzburg, Germany
  • HOLCAR, Marija, LENASSI, Metka. Extracellular vesicles as biomarkers (of treatment response).
    ESHG Pharmacogenetics Course: Portorož, Slovenija, 22. – 24. 9. 2022, Portorož, Slovenia
  • LENASSI, Metka. Reference values of blood EVs.
    ISEV workshop - Blood EVs, Educational day, 31. 8. 2022, Helsinki, Finland
  • SEDEJ, Ivana, ŠTALEKAR, Maja, TUŠEK-ŽNIDARIČ, Magda, GORIČAR, Katja, KOJC, Nika, KOGOVŠEK, Polona, DOLŽAN, Vita, ARNOL, Miha, LENASSI, Metka. Urinary extracellular vesicle bound DNA for the detection of kidney allograft injury.
    Extracellular Vesicles: from Fundamental Research to Clinical Application: workshop: Ljubljana, 20. 6. 2022, Ljubljana, Slovenia
  • SEDEJ, Ivana, ŠTALEKAR, Maja, TUŠEK-ŽNIDARIČ, Magda, GORIČAR, Katja, KOJC, Nika, KOGOVŠEK, Polona, DOLŽAN, Vita, LENASSI, Metka, ARNOL, Miha. Kidney allograft injury is reflected in the DNA cargo of urinary extracellular vesicles.
    2022 American Transplant Congress: 4. – 8. 6. 2022, Boston, USA
  • SEDEJ, Ivana, ŠTALEKAR, Maja, TUŠEK-ŽNIDARIČ, Magda, GORIČAR, Katja, KOJC, Nika, KOGOVŠEK, Polona, DOLŽAN, Vita, ARNOL, Miha, LENASSI, Metka. DNA bound to the surface of urine extracellular vesicles as potential kidney allograft injury biomarker.
    ISEV2022: 2022 ISEV22 Annual Meeting:25. – 29. 5. 2022, Lyon, France
  • LENASSI, Metka. Pros and cons of EV preparation methods.
    ISEV 2022 Annual Meeting, Education day, 24. 5. 2022, Lyon, France

    • 2021

  • BADOVINAC, David, LENASSI, Metka, ZAVRTANIK, Hana, TOMAŽIČ, Aleš. Diagnostic value of extracellular vesicles in pancreatic cancer.
    5. kongres Slovenskega združenja za gastroenterologijo, 19. – 20. 11. 2021, Maribor, Slovenia
  • SEDEJ, Ivana, ŠTALEKAR, Maja, KOGOVŠEK, Polona, DOLŽAN, Vita, LENASSI, Metka, ARNOL, Miha. Urinary extracellular vesicles and vesicular cell-free DNA as potential biomarkers for kidney allograft injury.
    20th Congress of the European Society for Organ Transplantation, 29. 8. – 1. 9. 2021, Milan, Italy
  • LAVRIN, Teja, HUDOKLIN, Samo, VERANIČ, Peter, PLEMENITAŠ, Ana, LENASSI, Metka. Fungal extracellular particles and their relevance in adaptation to osmotic stress.
    45th FEBS Congress, Molecules of Life: Towards New Horizons, 3. – 8. 6. 2021, Ljubljana, Slovenia
  • HOLCAR, Marija, FERDIN, Jana, SITAR, Simona, TUŠEK-ŽNIDARIČ, Magda, DOLŽAN, Vita, PLEMENITAŠ, Ana, ŽAGAR, Ema, LENASSI, Metka. Method of enrichment of human plasma extracellular vesicles for reliable quantification for biomarker discovery.
    45th FEBS Congress, Molecules of Life: Towards New Horizons, 3. – 8. 6. 2021, Ljubljana, Slovenia
  • HOLCAR, Marija, ŠTOK, Ula, SITAR, Simona, TUŠEK-ŽNIDARIČ, Magda, PLEMENITAŠ, Ana, ŽAGAR, Ema, DOLŽAN, Vita, SODIN-ŠEMRL, Snežna, ČUČNIK, Saša, ŽIGON, Polona, LENASSI, Metka. Simple density-based method for enrichment of plasma-EVs and its use in biomarker discovery for thrombotic antiphospholipid syndrome.
    ISEV2021: ISEV21 Annual Meeting:18. – 21. 05. 2021 (virtual conference)
  • HOLCAR, Marija. Kri kot vir zunajceličnih veziklov: od bioloških vzorcev do molekularnih označevalcev.
    Šola farmakogenetike: 9. 4. 2021, Ljubljana, Slovenia
  • LENASSI, Metka. Zunajcelični vezikli kot potencialni molekularni označevalci.
    Šola farmakogenetike, 9. 4. 2021, Ljubljana, Slovenia
  • SEDEJ, Ivana, TUŠEK-ŽNIDARIČ, Magda, DOLŽAN, Vita, LENASSI, Metka, ARNOL, Miha. Optimization of isolation protocol and characterization of urinary extracellular vesicles as biomarkers for kidney allograft injury.
    7th Slovenian Congress of Nephrology: 11. 3. – 14. 3. 2021, Ljubljana, Slovenia
  • LENASSI, Metka. Viral protein Nef promotes EV release and HIV pathogenesis.
    ISEV 2021 Infectious Diseases and Extracellular Vesicles, an ISEV Meeting, 25. – 28. 1. 2021, Virtual

    • 2020

  • HOLCAR, Marija, FERDIN, Jana, SITAR, Simona, TUŠEK-ŽNIDARIČ, Magda, DOLŽAN, Vita, PLEMENITAŠ, Ana, ŽAGAR, Ema, LENASSI, Metka. Method for reliable enrichment of plasma extracellular vesicles for biomarker discovery.
    Socratic Symposium, 11. 12. 2020, Ljubljana, Slovenia
  • MARIĆ, Ivica, LENASSI, Metka. Analiza koncentracije in velikosti zunajceličnih veziklov, izoliranih iz krvne plazme, pri zdravi slovenski populaciji.
    Raziskovalni dan Zavoda Republike Slovenije za transfuzijsko medicino 2020: 29. 5. 2020, Ljubljana, Slovenia

    • 2019

  • SEDEJ, Ivana, TUŠEK-ŽNIDARIČ, Magda, DOLŽAN, Vita, ARNOL, Miha, LENASSI, Metka. Extracellular vesicles from urine in kidney transplant recipients: optimization of the isolation method.
    Extracellular vesicles: mediators and biomarkers of pathology: 5. 12. 2019, Ljubljana, Slovenia
  • BADOVINAC, David, GORIČAR, Katja, ZAVRTANIK, Hana, PETRIČ, Miha, LAVRIN, Teja, MAVEC, Nina, DOLŽAN, Vita, TOMAŽIČ, Aleš, LENASSI, Metka. Characteristics of plasma extracellular vesicles in pancreatic ductal adenocarcinoma.
    Extracellular vesicles: mediators and biomarkers of pathology: 5. 12. 2019, Ljubljana, Slovenia
  • HOLCAR, Marija, FERDIN, Jana, SITAR, Simona, TUŠEK-ŽNIDARIČ, Magda, DOLŽAN, Vita, PLEMENITAŠ, Ana, ŽAGAR, Ema, LENASSI, Metka. Enrichment of plasma extracellular vesicles for reliable quantification for biomarker discovery.
    Extracellular vesicles: mediators and biomarkers of pathology: 5. 12. 2019, Ljubljana, Slovenia
  • LAVRIN, Teja, KOSTANJŠEK, Rok, HUDOKLIN, Samo, VERANIČ, Peter, GUNDE-CIMERMAN, Nina, PLEMENITAŠ, Ana, LENASSI, Metka. Fungal extracellular vesicles and their relevance in ecology and pathogenicity.
    Extracellular vesicles: mediators and biomarkers of pathology: 5. 12. 2019, Ljubljana, Slovenia
  • SEDEJ, Ivana, LENASSI, Metka, DOLŽAN, Vita, ARNOL, Miha. Identification of biomarkers for early detection of kidney allograft dysfunction.
    13th Meeting of the Slovenian Biochemical Society with International Participation: 24. – 27. 9. 2019, Dobrna, Slovenia
  • LAVRIN, Teja, BADOVINAC, David, ZAVRTANIK, Hana, MAVEC, Nina, GORIČAR, Katja, SITAR, Simona, PLEMENITAŠ, Ana, ŽAGAR, Ema, KOSTANJŠEK, Rok, ROGELJ, Boris, DOLŽAN, Vita, GUNDE-CIMERMAN, Nina, TOMAŽIČ, Aleš, LENASSI, Metka. Extracellular vesicle cargo and morphology as potential diagnostic tools for neurodegenerative diseases and cancer.
    13th Meeting of the Slovenian Biochemical Society with International Participation: 24. – 27. 9. 2019, Dobrna, Slovenia
  • HOLCAR, Marija, FERDIN, Jana, SITAR, Simona, TUŠEK-ŽNIDARIČ, Magda, MAVEC, Nina, GORIČAR, Katja, PLEMENITAŠ, Ana, ŽAGAR, Ema, DOLŽAN, Vita, LENASSI, Metka. Development of a method for extracellular vesicles isolation from human blood and evaluation of its clinical value in malignant mesothelioma.
    13th Meeting of the Slovenian Biochemical Society with International Participation: 24. – 27. 9. 2019, Dobrna, Slovenia
  • LAVRIN, Teja, BADOVINAC, David, ZAVRTANIK, Hana, SITAR, Simona, ŽAGAR, Ema, PLEMENITAŠ, Ana, KOSTANJŠEK, Rok, ROGELJ, Boris, GUNDE-CIMERMAN, Nina, TOMAŽIČ, Aleš, LENASSI, Metka. Extracellular vesicles as a potential diagnostic tool for neurodegenerative diseases and cancer.
    III Mediterranean Institute for Life Sciences: Advances in Biomedical Research: 17. – 21. 6. 2019, Split, Croatia
  • KONTE, Tilen, LAVRIN, Teja, HUDOKLIN, Samo, VERANIČ, Peter, SITAR, Simona, ŽAGAR, Ema, LENASSI, Metka, PLEMENITAŠ, Ana. Isolation and characterization of extracellular vesicles produced by the halophilic/halotolerant fungi Wallemia ichthyophaga and Hortaea werneckii.
    30th Fungal Genetics Conference, 12. - 17. 3. 2019, Pacific Grove, USA
  • LENASSI, Metka. Raziskave zunajceličnih veziklov v medicini.
    Mala šola farmakogenetike, 2. 3. 2019, Ljubljana, Slovenia


    • Awards:

    2021

  • HOLCAR, Marija, … LENASSI, Metka. Enrichment of plasma extracellular vesicles for reliable quantification of their size and concentration for biomarker discovery. Award: Excellent in science award for the most prominent achievements of past year (2021), Slovenian Research and Innovation Agency (COBISS.SI-ID 41337603)

    • 2019

  • Metka Lenassi received Lavrič's award for the best teaching assistant at UL Faculty of Medicine in 2019


    • Several of our students have been recognized for their research work:

    2023

  • VUKOLIĆ, Lan, ŽVAR Tjaš. Extracellular vesicle-bound miRNAs as potential biomarkers for noninvasive detection of kidney transplant rejection. Ljubljana, 2023, [Co-mentor: Metka Lenassi]
    Award: Faculty of Medicine Prešeren Award for Excellence in Research

    • 2021

  • MLINŠEK Teo. Analysis of small non-coding RNAs from urinary extracellular vesicles in Fabry disease. Faculty of Medicine, University of Ljubljana, 2021, [Co-mentor: Marija Holcar]
    Awards: Faculty of Medicine Prešeren Award for Excellence in Research; Krka Award for Student Research Project
  • SMOLAR, Janja, ŠTURM INDIHAR, Blažka. Evaluacija koncentracije in velikosti zunajceličnih veziklov iz krvne plazme kot biološkega označevalca stopnje diferenciacije tumorja pri bolnikih z adenokarcinomom trebušne slinavke. [COBISS.SI-ID 134211843], [Mentor: Metka Lenassi]
    Awards: Faculty of Medicine Prešeren Award for Excellence in Research; Krka Award for Student Research Project

    • 2017

  • HLADNIK, Anžej. Evaluacija virusne TAR RNA in humane mikro RNA hsa-miR-20a-5p kot biooznačevalcev za telesne rezervoarje virusa HIV-1. [COBISS.SI-ID 3898132], [Mentor: Metka Lenassi]
    Awards: Faculty of Medicine Prešeren Award for Excellence in Research; Krka Award for Student Research Project

    • 2013

  • GLOBOČNIK, Sara. Biokemijska karakterizacija encima Hal2, ključnega za toleranco kvasovk na natrijeve ione. [COBISS.SI-ID 3670804], [Co-mentor: Metka Lenassi]
    Award: Faculty of Medicine Prešeren Award for Excellence in Research
    		•