Molekulski mehanizmi uravnavanja celičnih procesov v povezavi z nekaterimi boleznimi pri človeku
Molecular mechanisms of regulation of cellular processes related to some human diseaes
OPIS PROJEKTA / DESCRIPTION
Molekularni mehanizmi, ki so vpleteni v regulacijo celičnih procesov so ključni za vzdrževanje homeostaze, obrambo pred okoljskimi ali endogenimi stresorji in popravo poškodb. Za boljše razumevanje molekularnih mehanizmov, ki uravnavajo celične procese v zdravju in bolezni, bomo osnovne raziskave na izoliranih encimih, modelnih organizmih, celičnih linijah in človeških tkivih nadgradili z aplikativnimi raziskavami in kliničnimi študijami. Translacijski cilj našega programa je najti nove potencialne diagnostične in prognostične označevalce, opredeliti in raziskati nove tarče zdravljenja in farmakogenetske označevalce odgovora na zdravljenje za osebno medicino.
Molecular mechanisms implicated in regulation of cellular processes are crucial for maintainance of homeostasis, defence against environmental or endogenous stressors and damage repair. We will combine basic research on isolated enzymes, model organisms, cell lines and human tissues with applied research and clinical studies with a goal of better understanding of molecular mechanisms that regulate these cellular processes in health and disease. The translational aspect of our programme is to find new potential diagnostic and prognostic biomarkers, identify and investigate novel targets for treatment and pharmacogenomic markers of treatment response that will support individualized medicine.
